MMRF May 05 Booklet_New.qxd
نویسندگان
چکیده
Lactoferrin is an iron-binding glycoprotein that belongs to the transferrin family. It is present in breast milk, in epithelial secretions, and in the secondary granules of neutrophils. In healthy subjects lactoferrin circulates at concentrations of 2-7 x 10-6 g/ml. Lactoferrin is a pleiotropic factor with potent antimicrobial and immunomodulatory activities. Recently, we have shown that lactoferrin can also promote bone growth.At physiological concentrations, lactoferrin potently stimulates the proliferation and differentiation of primary osteoblasts and also acts as a survival factor inhibiting apoptosis induced by serum withdrawal. Lactoferrin also affects osteoclast formation and, in murine bone marrow culture, lactoferrin potently inhibits osteoclastogenesis. In vivo, local injection of lactoferrin above the hemicalvaria of adult mice results in substantial increases in the dynamic histomorphometric indices of bone formation and bone area.
منابع مشابه
MMRF May 05 Booklet_New.qxd
Community-associated methicillin-resistant Staphylococcus aureus (CAMRSA) infections are an emerging problem in the United States and many parts of the world. These infections originate in communities as opposed to hospital-acquired MRSA (HA-MRSA) infections. If adequate measures are not taken to thoroughly understand and control its changing epidemiology and clinical presentation, it may becom...
متن کاملMMRF Aug 05 Booklet_New.qxd
Results: Forty-three of 117 patients had no prior warfarin treatment and were eligible. Five declined to participate.Twenty patients were randomized to a standard initiation dose of 5 mg daily. Eighteen patients were randomized to model-based dosing. All but one participant received the assigned initiation dose. Blood draw to dosage calculation time (including genotyping) required approximately...
متن کاملMMRF May 05 Booklet_New.qxd
As the number of preand post-transplant solid organ recipients continues to grow, it becomes important for all physicians to have an understanding of the process of organ procurement and allocation. In the United States, the current system for allocation and transplantation of human solid organs has been heavily influenced by the experience in deceased donor liver transplantation (DDLT). This r...
متن کاملMMRF May 05 Booklet_New.qxd
Bone marrow failure is a disease characterized by a drastic decline in the marrow’s functional ability to produce mature blood cells.Aplastic anemia, a disease in which patients have essentially empty bone marrow accompanied by severe anemia, neutropenia, and thrombocytopenia, presents a paradigm for bone marrow failure. Damage to the marrow may first result from exposure to toxic chemicals, dr...
متن کاملMMRF Feb 06 Booklet_New.qxd
Reprint Requests: Fousseyni S. Touré, PhD, Centre International de Recherches, Médicales de Franceville, BP 769 Franceville, Gabon, Tel: 00 241 06615636; Fax: 00 241 677095; E-mail: [email protected] Received: November 2, 2005 Revised: January 11, 2006 Accepted: January 18, 2006 Grant Support: State of Gabon, by Total-Fina-Elf and by the French Ministry of Foreign Affairs
متن کاملMMRF May 05 Booklet_New.qxd
Gorham’s disease, also known as vanishing bone disease and massive osteolysis is a very rare disorder of unknown etiology characterized by uncontrolled proliferation of vascular or lymphatic capillaries within bone.1 As the endothelial cells proliferate, they aggressively yet painlessly invade the adjacent bone, leading to resorption and replacement with angiomatous tissue. Surrounding soft tis...
متن کامل